Main Approaches to Controlled Protein Degradation in the Cell

被引：0

作者：

Kapitonova, M. A. ^{[1
]}

Shadrina, O. A. ^{[1
,2
]}

Korolev, S. P. ^{[2
]}

Gottikh, M. B. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Chem Fac, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

来源：

MOLECULAR BIOLOGY | 2021年 / 55卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

ubiquitination; proteasomal degradation; auxin; degron; inducible degradation; optogenetic approach; INDUCIBLE DEGRON SYSTEM; F-BOX; PROTEASOMAL DEGRADATION; STRUCTURAL BASIS; AUXIN; UBIQUITINATION; JASMONATE; COMPLEX; MOLECULES; DEPLETION;

D O I：

10.1134/S0026893321030067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the most informative methods to study the roles of individual proteins in cell functions is based on changing their intracellular concentrations. Genetic knockouts or knockdowns are most commonly used for the purpose. However, acting directly at the level of an expressed protein is more informative or convenient to perform in some cases. This action should ideally be controlled in time and reversible. The review analyzes the current data on systems developed to achieve controlled degradation of proteins via their ubiquitination with subsequent proteasome-mediated degradation or other mechanisms.

引用

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页码：470 / 486

页数：17

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