Hepatitis B virus reactivation after effective sofosbuvir and ribavirin treatment in a patient with occult hepatitis B virus infection

被引：0

作者：

Odolini, Silvia ^{[1
,2
]}

Lanza, Paola ^{[1
,2
]}

Spinetti, Angiola ^{[1
,2
]}

Zaltron, Serena ^{[1
,2
]}

Urbinati, Lucia ^{[1
,2
]}

Vavassori, Andrea ^{[1
,2
]}

Nasta, Paola ^{[1
,2
]}

Festa, Elena ^{[1
,2
]}

Gargiulo, Franco ^{[3
]}

Rodella, Anna ^{[3
]}

Caruso, Arnaldo ^{[3
]}

Casari, Salvatore ^{[1
,2
]}

Castelli, Francesco ^{[1
,2
]}

Vigano, Mauro ^{[4
]}

机构：

[1] Univ Brescia, Clin Infect & Trop Dis, Brescia, Italy

[2] Spedali Civil Brescia, Gen Hosp, Brescia, Italy

[3] Brescia Spedali Civili, Lab Microbiol, Gen Hosp, Brescia, Italy

[4] Univ Milan, Hepatol Unit, Osped San Giuseppe, Milan, Italy

来源：

NEW MICROBIOLOGICA | 2017年 / 40卷 / 03期

关键词：

Reactivation; DAAs; HCV; Occult B hepatitis; C-VIRUS; COINFECTION; THERAPY;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Reactivation of the hepatitis B virus (HBV) has been reported in patients with occult infection (OBI), i. e. HBV surface antigen (HBsAg) negative, HBV core antibody (anti-HBc) positive +/- antibodies against HBsAg (anti-HBs) and detectable HBV DNA in serum or liver, receiving immunosuppressive or cytotoxic therapies. Recently, concerns have been raised regarding the risk of HBV reactivation in OBI patients treated with direct acting antiviral agents (DAAs) for chronic hepatitis C (CHC). Here we describe a case of HBV reactivation in a 72-year-old woman with OBI as a possible consequence of effective treatment with sofosbuvir (SOF) and ribavirin (Rbv) for genotype 2a/2c CHC.

引用

页码：218 / 220

页数：3

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