ASYMMETRIC BIOTRANSFORMATIONS IN CONTINUOUS FLOW REACTORS

被引：0

作者：

Boros, Zoltan ^{[1
]}

Szigeti, Mariann ^{[1
]}

Tomin, Anna ^{[1
]}

Kovacs, Peter ^{[2
]}

Uerge, Laszlo ^{[3
]}

Darvas, Ferenc ^{[3
]}

Poppe, Laszlo ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

[2] Hungarian Acad Sci, Chem Res Ctr, Inst Biomol Chem, Dept Synthet Organ Chem, H-1025 Budapest, Hungary

[3] ThalesNano Nanotechnol Inc, H-1031 Budapest, Hungary

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2009年 / 54卷

基金：

美国国家科学基金会;

关键词：

lipase; continuous flow reactor; asymmetric biotransformation; KINETIC RESOLUTION; LIPASE; ENANTIOMER; ALCOHOLS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric acetylations of prochiral diols 3a-d with isopropenyl acetate were investigated with different commercial and self prepared lipases. Continuous flow mode reactions were performed in small stainless steel packed-bed reactors which can precisely control temperature (-10-200 degrees C), pressure (0-150 bar) and flow rate (0.1-3.0 mL/min). The effect of the temperature and flow-rate on the conversion and enantiomer excess of the chiral monoesters was investigated.

引用

页码：69 / 75

页数：7

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