Pain perception and processing in individuals with posttraumatic stress disorder: a systematic review with meta-analysis

被引:16
|
作者
Tesarz, Jonas [1 ]
Baumeister, David [1 ]
Andersen, Tonny Elmose [2 ]
Vaegter, Henrik Bjarke [3 ,4 ]
机构
[1] Heidelberg Univ, Med Hosp, Dept Gen Internal Med & Psychosomat, Neuenheimer Feld 410, D-69120 Heidelberg, Germany
[2] Univ Southern Denmark, Dept Psychol, Odense, Denmark
[3] Univ Hosp Odense, Pain Ctr, Dept Anesthesiol & Intens Care Med, Pain Res Grp, Odense, Denmark
[4] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark
关键词
Posttraumatic stress; PTSD; Somatosensory testing; QST; Systematic review; Meta-analysis; Combat; Trauma; Stress; Pain threshold; Pain tolerance; Pain sensitivity; Conditioned pain modulation; Wind-up; BORDERLINE PERSONALITY-DISORDER; SENSITIVITY; PTSD; HETEROGENEITY; COMORBIDITY; SYMPTOMS; VETERANS; ASSOCIATION; DISABILITY; DEPRESSION;
D O I
10.1097/PR9.0000000000000849
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Posttraumatic stress disorder (PTSD) is a known risk factor for the development of chronic pain conditions, and almost 1 in 5 individuals with chronic pain fulfills the criteria for PTSD. However, the relationship between PTSD and pain is poorly understood and studies on pain perception in patients with PTSD show inconsistent results suggesting that different sensory profiles exist among individuals with PTSD. Here, we (1) systematically summarize the current literature on experimentally evoked pain perception in patients with PTSD compared to subjects without PTSD, and (2) assess whether the nature of the traumatic event is associated with different patterns in pain perception. The main outcome measures were pain threshold, pain tolerance, and pain intensity ratings as well as measures of temporal summation of pain and conditioned pain modulation. A systematic search of MEDLINE, EMBASE, Web of Science, PsycINFO, and CINAHL identified 21 studies for the meta-analysis, including 422 individuals with PTSD and 496 PTSD-free controls. No main effect of PTSD on any outcome measure was found. However, stratification according to the nature of trauma revealed significant differences of small to medium effect sizes. Combat-related PTSD was associated with increased pain thresholds, whereas accident-related PTSD was associated with decreased pain thresholds. No clear relationship between PTSD and experimentally evoked pain perception exists. The type of trauma may affect pain thresholds differently indicating the presence of different subgroups with qualitative differences in pain processing.
引用
下载
收藏
页数:7
相关论文
共 50 条
  • [21] Preventing posttraumatic stress disorder following childbirth: a systematic review and meta-analysis
    Dekel, Sharon
    Papadakis, Joanna E.
    Quagliarini, Beatrice
    Pham, Christina T.
    Pacheco-Barrios, Kevin
    Hughes, Francine
    Jagodnik, Kathleen M.
    Nandru, Rasvitha
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2024, 230 (06) : 610 - 641.e14
  • [22] Posttraumatic stress disorder and risk of suicidal behavior: A systematic review and meta-analysis
    Akbar, Rahat
    Arya, Vikas
    Conroy, Elizabeth
    Wilcox, Holly C.
    Page, Andrew
    SUICIDE AND LIFE-THREATENING BEHAVIOR, 2023, 53 (01) : 163 - 184
  • [23] ASSOCIATION OF THYROID FUNCTION WITH POSTTRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSIS
    Toloza, Freddy J. K.
    Mao, Yuanjie
    Menon, Lakshmi P.
    George, Gemy
    Borikar, Madhura
    Erwin, Patricia J.
    Owen, Richard R.
    Maraka, Spyridoula
    ENDOCRINE PRACTICE, 2020, 26 (10) : 1173 - 1185
  • [24] Suicidality and posttraumatic stress disorder (PTSD) in adolescents: a systematic review and meta-analysis
    Panagioti, Maria
    Gooding, Patricia A.
    Triantafyllou, Kalliopi
    Tarrier, Nicholas
    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2015, 50 (04) : 525 - 537
  • [25] Ketamine in the effective management of chronic pain, depression, and posttraumatic stress disorder for Veterans: A meta-analysis and systematic review
    Liu, Jenny J. W.
    Ein, Natalie
    Gervasio, Julia
    Baker, Clara
    Plouffe, Rachel
    Wanklyn, Sonya
    Burhan, Amer M.
    Lau, Brenda
    Abreu, Emmanuel
    Wasiuta, Thomas
    Nazarov, Anthony
    Richardson, J. Don
    FRONTIERS IN PSYCHIATRY, 2024, 15
  • [26] Allegiance effects in cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD): a systematic review and meta-analysis
    Maddox, Claire-Sophie
    Berle, David
    CLINICAL PSYCHOLOGIST, 2024, 28 (02) : 79 - 93
  • [27] Meditation for Posttraumatic Stress: Systematic Review and Meta-Analysis
    Hilton, Lara
    Maher, Alicia Ruelaz
    Colaiaco, Benjamin
    Apaydin, Eric
    Sorbero, Melony E.
    Booth, Marika
    Shanman, Roberta M.
    Hempel, Susanne
    PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY, 2017, 9 (04) : 453 - 460
  • [28] Light sedation strategies and posttraumatic stress disorder: a systematic review and network meta-analysis
    Antonio Paulo Nassar Junior
    Fernando G Zampieri
    Otavio T Ranzani
    Marcelo Park
    Critical Care, 19 (Suppl 2):
  • [29] Therapeutic alliance in psychological therapy for posttraumatic stress disorder: A systematic review and meta-analysis
    Howard, Ruth
    Berry, Katherine
    Haddock, Gillian
    CLINICAL PSYCHOLOGY & PSYCHOTHERAPY, 2022, 29 (02) : 373 - 399
  • [30] The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis
    Wang, Jing
    Ouyang, Hui
    Jiao, Runda
    Cheng, Suhui
    Zhang, Haiyan
    Shang, Zhilei
    Jia, Yanpu
    Yan, Wenjie
    Wu, Lili
    Liu, Weizhi
    NPJ DIGITAL MEDICINE, 2024, 7 (01)