Free laminin in the extracellular matrix of B-cell non Hodgkin's lymphomas

被引:0
|
作者
Ribatti, D
Vacca, A
Nico, B
Quondamatteo, F
Herken, R
Roncali, L
机构
[1] Univ Bari, Sch Med, Inst Human Anat Histol & Embryol, Bari, Italy
[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Bari, Italy
[3] Univ Gottingen, Histol Lab, Ctr Anat, D-3400 Gottingen, Germany
关键词
B-cell non Hodgkin's lymphomas; laminin; angiogenesis; tumor progression;
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The authors show that in the perivascular stroma of B-cell non-Hodgkin's lymphomas (B-NHL) is present a granular, speckled pattern of expression of laminin, similar to the 'free-laminin' firstly described by Lugassy et al. (1997) in human melanoma. The role of this form of laminin may be to promote the migration of tumor cells, which express a variety of binding-laminin surface proteins, whose expression is significantly increased in several human cancer models.
引用
收藏
页码:459 / 461
页数:3
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