Gut microbiota aggravate cardiac ischemia-reperfusion injury via regulating the formation of neutrophils extracellular traps

被引:11
|
作者
Chen, Chunxia [1 ]
Zhang, Hao [1 ]
Xie, Ran [1 ]
Wang, Yaohui [1 ]
Ma, Yuanfang [1 ]
机构
[1] Henan Univ, Affiliated Hosp 1, Joint Natl Lab Antibody Drug Engn, Kaifeng 475004, Peoples R China
关键词
MI; I; R injury; Gut microbiota; NETs; INTESTINAL MICROBIOTA; CARDIOVASCULAR HEALTH; MYOCARDIAL-INFARCTION;
D O I
10.1016/j.lfs.2022.120670
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aims: Myocardial infarction (MI) is a leading cause of death worldwide for which there is no cure. Percutaneous coronary intervention (PCI) can restore blood supply in a timely manner, which greatly reduces the mortality of patients, but ischemia/reperfusion (I/R) injury is inevitable. A number of clinical studies have shown that gut microbiota play an essential role in cardiovascular diseases. This study aims to explore the mechanism of gut microbiota to limit I/R injury.Materials and methods: This study adopted the myocardial I/R model using gut microbiota clearance mice, neutrophil clearance mice and double-scavenging mice, and explored the relationship between gut microbiota and NETs during I/R injury. Neutrophils were isolated in vitro to explore the effect of NETs on myocardial cell injury and its molecular mechanism.Key findings: Gut microbiota aggravate cardiac I/R injury via regulating the formation of NETs. The migration of gut microbiota to blood stimulated the formation of NETs after cardiac I/R. NETs, which can directly lead to apoptosis of myocardial cells and myocardial microvascular endothelial cells. The time point of NETs formation in tissue and blood after I/R were determined by experiments. Significance: It was confirmed that gut microbiota participates in cardiac I/R injury by regulating the formation of NETs, which reveals a new mechanism of I/R injury and provides a new potential target for the treatment of I/R injury.
引用
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页数:11
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