Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

被引：11
|
作者：
Drewniak, Magda [1 ]
Weglarz-Tomczak, Ewelina [1 ]
Ozga, Katarzyna [1 ]
Rudzinska-Szostak, Ewa [1 ]
Macegoniuk, Katarzyna [1 ]
Tomczak, Jakub M. [2 ]
Bejger, Magdalena [3 ]
Rypniewski, Wojciech [3 ]
Berlicki, Lukasz [1 ]
机构：
[1] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, Wybrzeie Wyspianiskiego 27, PL-50370 Wroclaw, Poland
[2] Univ Amsterdam, Amsterdam Machine Learning Lab, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands
[3] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland
来源：
BIOORGANIC CHEMISTRY | 2018年 / 81卷
关键词：
Foldamers; Peptides; Conformation; Circular dichroism; Nuclear magnetic resonance; Catalysis; ALPHA/BETA-PEPTIDES; CRYSTALLOGRAPHIC CHARACTERIZATION; HETEROGENEOUS BACKBONES; SECONDARY STRUCTURES; BETA-PEPTIDES; PROTEIN; ACID; CHEMISTRY; DESIGN; EVOLUTION;
D O I：
10.1016/j.bioorg.2018.07.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.
引用
收藏
页码：356 / 361
页数：6
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