Controlling Ca2+ Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

被引：10
|
作者：
Norager, Niels G. [1 ]
Poulsen, Mette H. [1 ]
Stromgaard, Kristian [1 ]
机构：
[1] Univ Copenhagen, Dept Drug Design & Pharmacol, Univ Pk 2, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 61卷 / 17期
关键词：
IONOTROPIC GLUTAMATE RECEPTORS; SOLID-PHASE SYNTHESIS; POLYAMINE TOXINS; CAGED GLUTAMATE; NMDA RECEPTORS; OPTICAL SWITCH; POTENT; OPTOGENETICS; AZOBENZENE; INSIGHTS;
D O I：
10.1021/acs.jmedchem.8b00756
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ionotropic glutamate receptors (iGluRs) play a critical role in normal brain function and neurodegenerative diseases. Development of light-dependent compounds would enable studies of iGluRs within intact mammalian neural tissue, as light is noninvasive and can be applied with high spatiotemporal precision. Here we develop a potent photochromic antagonist that selectively targets the Ca2+ permeable AMPA-type of iGuRs, thus providing an important tool to study the contribution of AMPA-type iGluRs on neuronal activity.
引用
收藏
页码：8048 / 8053
页数：6
相关论文
共 50 条
  • [31] INTRACELLULAR POLYAMINES MEDIATE INWARD RECTIFICATION OF CA2+-PERMEABLE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS
    DONEVAN, SD
    ROGAWSKI, MA
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9298 - 9302
  • [32] Functional characterization of YM928, a novel noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist
    Ohno, K
    Tsutsumi, R
    Matsumoto, N
    Yamashita, H
    Amada, Y
    Shishikura, JI
    Yatsugi, HISI
    Okada, M
    Sakamoto, S
    Yamaguchi, T
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 306 (01): : 66 - 72
  • [33] Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists
    Welch, WM
    Ewing, FE
    Huang, J
    Menniti, FS
    Pagnozzi, MJ
    Kelly, K
    Seymour, PA
    Guanowsky, V
    Guhan, S
    Guinn, MR
    Critchett, D
    Lazzaro, J
    Ganong, AH
    DeVries, KM
    Staigers, TL
    Chenard, BL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (02) : 177 - 181
  • [34] Diastereomeric salt resolution based synthesis of LY503430, an AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) potentiator
    Magnus, NA
    Aikins, JA
    Cronin, JS
    Diseroad, WD
    Hargis, AD
    LeTourneau, ME
    Parker, BE
    Reutzel-Edens, SM
    Schafer, JP
    Staszak, MA
    Stephenson, GA
    Tameze, SL
    Zollars, LMH
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2005, 9 (05) : 621 - 628
  • [35] GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors
    Guntupalli, Sumasri
    Jang, Se Eun
    Zhu, Tianyi
    Huganir, Richard L.
    Widagdo, Jocelyn
    Anggono, Victor
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (20) : 8186 - 8194
  • [36] Effects of Quercetin on Human α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor-Mediated Ion Currents
    Shin, Tae-Joon
    Choi, Sun-Hye
    Lee, Byung-Hwan
    Pyo, Mi Kyung
    Hwang, Sung-Hee
    Kim, Bo-Ra
    Lee, Sang-Mok
    Han, Ye Sun
    Lee, Jun-Ho
    Park, Ji-Ho
    Kim, Hyoung-Chun
    Rhim, Hyewhon
    Nah, Seung-Yeol
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2010, 33 (09) : 1615 - 1619
  • [37] Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
    Salussolia, Catherine L.
    Corrales, Alexandra
    Talukder, Iehab
    Kazi, Rashek
    Akgul, Gulcan
    Bowen, Mark
    Wollmuth, Lonnie P.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (46) : 40205 - 40218
  • [38] Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors
    Hsu, Wei-Lun
    Chung, Hui-Wen
    Wu, Chih-Yueh
    Wu, Huei-Ing
    Lee, Yu-Tao
    Chen, En-Chan
    Fang, Weilun
    Chang, Yen-Chung
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (34) : 20748 - 20760
  • [39] Diabetes causes transient changes in the composition and phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina
    Castilho, Aurea F.
    Liberal, Joana T.
    Baptista, Filipa I.
    Gaspar, Joana M.
    Carvalho, Ana Luisa
    Ambrosio, Antonio F.
    MOLECULAR VISION, 2014, 20 : 894 - 907
  • [40] An α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist and an N-methyl-D-aspartate (NMDA) channel blocker synergistically impair spatial memory in rats
    Li, HB
    Matsumoto, K
    Watanabe, H
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (11) : 1228 - 1230
12345