A rationally designed cocatalyst for the Morita-Baylis-Hillman reaction

被引：24
|
作者：
Jones, Charlotte E. S.
Turega, Simon M.
Clarke, Matthew L. [1 ]
Philp, Douglas
机构：
[1] Univ St Andrews, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 31期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/j.tetlet.2008.05.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The application of electronic structure calculations to a key transition state in the reaction manifold of the Morita-Baylis-Hillman reaction allows the design of two bis(thiourea) cocatalysts capable of accelerating this reaction through the hydrogen bond mediated recognition of both the nucleophile and the electrophile. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4666 / 4669
页数：4
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