Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas

被引：233
|
作者：
Jhiang, SM
Sagartz, JE
Tong, Q
ParkerThornburg, J
Capen, CC
Cho, JY
Xing, SH
Ledent, C
机构：
[1] OHIO STATE UNIV, CTR BIOTECHNOL, COLUMBUS, OH 43210 USA
[2] UNIV BRUSSELS, FAC MED, INST RECH INTERDISCIPLINAIRE, BRUSSELS, BELGIUM
来源：
ENDOCRINOLOGY | 1996年 / 137卷 / 01期
关键词：
D O I：
10.1210/en.137.1.375
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC1 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.
引用
收藏
页码：375 / 378
页数：4
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