Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo

被引：21
|
作者：
Larson, Bjorg [1 ]
Abeytunge, Sanjeewa [2 ]
Rajadhyaksha, Milind [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Dermatol, New York, NY 10022 USA
[2] Mem Sloan Kettering Canc Ctr, Res Engn Lab, New York, NY 10065 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 07期
基金：
美国国家卫生研究院;
关键词：
DIAGNOSTIC-ACCURACY; LENTIGO MALIGNA; IMPACT;
D O I：
10.1364/BOE.2.002055
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Point-scanning reflectance confocal microscopes continue to be successfully translated for detection of skin cancer. Line-scanning, with the use of a single scanner and a linear-array detector, offers a potentially smaller, simpler and lower cost alternative approach, to accelerate widespread dissemination into the clinic. However, translation will require an understanding of imaging performance deep within scattering and aberrating human tissues. We report the results of an investigation of the performance of a full-pupil line-scanning reflectance confocal microscope in human skin and oral mucosa, in terms of resolution, optical sectioning, contrast, signal-to-noise ratio, imaging and the effect of speckle noise. (C) 2011 Optical Society of America
引用
收藏
页码：2055 / 2067
页数：13
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