On the possibility of the nitric oxide formation upon biotransformation of hydroxamic acids

被引：5

作者：

Bogatyrenko, T. N. ^{[1
]}

Kuropteva, Z. V. ^{[2
]}

Baider, L. M. ^{[2
]}

Bogatyrenko, V. R. ^{[1
]}

Fedorov, B. S. ^{[1
]}

Konovalova, N. P. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia

[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2011年 / 60卷 / 06期

关键词：

nitric oxide; hydroxamic acids; nitro compounds; biotransformation; ESR spectroscopy; INHIBITORS; FAMILY;

D O I：

10.1007/s11172-011-0182-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Taking into account the data on oxidative transformation of hydroxamic acids to form nitric oxide and the similarity of their structure to the hydroxyarginine group being involved in the NO synthesis, we performed the study of biotransformation of salicylhydroxamic acid and N(4)-hydroxyasparagine in the liver tissues. According to the data from ESR spectroscopy, the compounds under study are inefficient NO donors in a biological system and their biological activities are mainly defined by the ability to chelate metal ions.

引用

页码：1162 / 1165

页数：4

共 50 条

[31] BIOTRANSFORMATION TO NITRIC-OXIDE OF ORGANIC NITRATES IN COMPARISON TO OTHER NITROVASODILATORS
FEELISCH, M
EUROPEAN HEART JOURNAL, 1993, 14 : 123 - 132
[32] Intravenous infusion of nitric oxide in experimental pulmonary hypertension: Biotransformation and haemodynamics
Pirrone, F.
Albertini, M.
Mazzola, S.
Pastore, C.
Clement, M. G.
Benfatto, M. C.
Aldini, G.
Carini, M.
VETERINARY RESEARCH COMMUNICATIONS, 2007, 31 (Suppl 1) : 185 - 187
[33] In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents
Qian, Meng
Liu, Qi
Wei, Yan
Guo, Zhikun
Zhao, Qiang
BIOACTIVE MATERIALS, 2021, 6 (05) : 1464 - 1467
[34] Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
Kokic, AN
Stevic, Z
Stojanovic, S
Blagojevic, DP
Jones, DR
Pavlovic, S
Niketic, V
Apostolski, S
Spasic, MB
REDOX REPORT, 2005, 10 (05) : 265 - 270
[35] THE ENZYMIC FORMATION OF HYDROXAMIC ACIDS FROM AMIDES AND PEPTIDES .2.
SLAVIK, K
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1951, 16 : 386 - 390
[36] THE ENZYMIC FORMATION OF HYDROXAMIC ACIDS FROM AMIDES AND PEPTIDES .1.
SLAVIK, K
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1951, 16 : 380 - 385
[37] THE FORMATION OF HYDROXAMIC ACIDS FROM PEPTIDES .3. THE SPECIFICITY OF GLUTATHIONASE
SLAVIK, K
PLUHAROVA, B
MATOULKOVA, V
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1954, 19 (06) : 1311 - 1315
[38] ON IDENTIFICATION OF HYDROXAMIC ACIDS FORMED BY NITRIC ACID DEGRADATION OF KEROSENE AND IOTA-DODECANE
OHWADA, K
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY-TOKYO, 1968, 5 (04): : 163 - &
[39] BIOCHEMICAL FORMATION AND PHARMACOLOGICAL, TOXICOLOGICAL, AND PATHOLOGICAL PROPERTIES OF HYDROXYLAMINES AND HYDROXAMIC ACIDS
WEISBURGER, JH
WEISBURGER, EK
PHARMACOLOGICAL REVIEWS, 1973, 25 (01) : 1 - 66
[40] Inhibition of nitric oxide formation by neuronal nitric oxide synthase by quinones: Nitric oxide synthase as a quinone reductase
Kumagai, Y
Nakajima, H
Midorikawa, K
Homma-Takeda, S
Shimojo, N
CHEMICAL RESEARCH IN TOXICOLOGY, 1998, 11 (06) : 608 - 613

← 1 2 3 4 5 →