On the possibility of the nitric oxide formation upon biotransformation of hydroxamic acids

被引：5
|
作者：
Bogatyrenko, T. N. [1 ]
Kuropteva, Z. V. [2 ]
Baider, L. M. [2 ]
Bogatyrenko, V. R. [1 ]
Fedorov, B. S. [1 ]
Konovalova, N. P. [1 ]
机构：
[1] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia
[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2011年 / 60卷 / 06期
关键词：
nitric oxide; hydroxamic acids; nitro compounds; biotransformation; ESR spectroscopy; INHIBITORS; FAMILY;
D O I：
10.1007/s11172-011-0182-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Taking into account the data on oxidative transformation of hydroxamic acids to form nitric oxide and the similarity of their structure to the hydroxyarginine group being involved in the NO synthesis, we performed the study of biotransformation of salicylhydroxamic acid and N(4)-hydroxyasparagine in the liver tissues. According to the data from ESR spectroscopy, the compounds under study are inefficient NO donors in a biological system and their biological activities are mainly defined by the ability to chelate metal ions.
引用
收藏
页码：1162 / 1165
页数：4
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