Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

被引：3

作者：

Agrawal, Rupesh ^{[1
,2
,3
,4
]}

Gunasekeran, Dinesh Visva ^{[1
,2
,3
]}

Agarwal, Aniruddha ^{[5
]}

Testi, Ilaria ^{[2
]}

Carreno, Ester ^{[6
]}

Westcott, Mark ^{[2
]}

Mahajan, Sarakshi ^{[7
]}

Raje, Dhananjay ^{[8
]}

Aggarwal, Kanika ^{[5
]}

Murthy, Somasheila, I ^{[9
]}

Chee, Soon-Phaik ^{[1
,4
,10
,11
,12
]}

Mccluskey, Peter ^{[13
]}

Ho, Su Ling ^{[1
]}

Teoh, Stephen ^{[1
]}

Cimino, Luca ^{[14
]}

Biswas, Jyotirmay ^{[15
]}

Narain, Shishir ^{[16
]}

Agarwal, Manisha ^{[17
]}

Mahendradas, Padmamalini ^{[18
]}

Khairallah, Moncef ^{[19
]}

Jones, Nicholas ^{[20
]}

Tugal-Tutkun, Ilknur ^{[21
]}

Babu, Kalpana ^{[22
]}

Basu, Soumayava ^{[6
,23
]}

Lee, Richard ^{[2
]}

Al-Dhibi, Hassan ^{[24
]}

Bodaghi, Bahram ^{[25
]}

Invernizzi, Alessandro ^{[26
]}

Goldstein, Debra A. ^{[27
]}

Herbort, Carl P. ^{[28
,29
]}

Barisani-Asenbauer, Talin ^{[30
]}

Gonzalez-Lopez, Julio J. ^{[31
]}

Androudi, Sofia ^{[32
]}

Bansal, Reema ^{[5
]}

Moharana, Bruttendu ^{[5
]}

Degli Esposti, Simona ^{[2
]}

Tasiopoulou, Anastasia ^{[2
]}

Nadarajah, Sengal ^{[2
]}

Agarwal, Mamta ^{[15
]}

Abraham, Sharanaya ^{[15
]}

Vala, Ruchi ^{[18
]}

Singh, Ramandeep ^{[5
]}

Sharma, Aman ^{[33
]}

Sharma, Kusum ^{[34
]}

Zierhut, Manfred ^{[35
]}

Kon, Onn Min ^{[36
]}

Cunningham, Emmett T. ^{[37
]}

Kempen, John H. ^{[38
,39
,40
]}

Quan Dong Nguyen ^{[7
]}

Pavesio, Carlos ^{[2
]}

机构：

[1] Tan Tock Seng Hosp, Natl Healthcare Grp Eye Inst, Singapore, Singapore

[2] Moorfields Eye Hosp, Natl Hlth Serv Fdn Trust, London, England

[3] Natl Univ Singapore, Sch Med, Singapore, Singapore

[4] Singapore Eye Res Inst, Singapore, Singapore

[5] Adv Eye Ctr, Postgrad Inst Med Educ & Res PGIMER, Chandigarh, India

[6] Hosp Univ Fdn Jimenez Diaz, Dept Oftalmol, Madrid, Spain

[7] Stanford Univ, Byers Eye Inst, Palo Alto, CA 94304 USA

[8] MDS Bioanalyt, Nagpur, Maharashtra, India

[9] LV Prasad Eye Inst, Tej Kohli Cornea Inst, Kallam Anji Reddy Campus, Hyderabad, India

[10] Singapore Natl Eye Ctr, Singapore, Singapore

[11] Duke NUS Med Sch, Dept Ophthalmol, Singapore, Singapore

[12] Duke NUS Med Sch, Visual Sci Acad Clin Program, Singapore, Singapore

[13] Univ Sydney, Cent Clin Sch, Save Sight Inst, Dept Clin Ophthalmol & Eye Hlth, Sydney, NSW, Australia

[14] Azienda USL IRCCS, Ocular Immunol Unit, Reggio Emilia, Italy

[15] Sankara Nethralaya, Dept Ophthalmol, Chennai, Tamil Nadu, India

[16] Shroff Eye Ctr, Dept Ophthalmol, New Delhi, India

[17] Dr Shroffs Char Eye Hosp Daryaganj, Dept Ophthalmol, New Delhi, India

[18] Narayana Nethralaya, Dept Uveitis & Ocular Immunol, Bangalore, Karnataka, India

[19] Univ Monastir, Fattouma Bourguiba Univ Hosp, Fac Med, Dept Ophthalmol, Monastir, Tunisia

[20] Univ Manchester, Dept Ophthalmol, Manchester, Lancs, England

[21] Istanbul Univ, Istanbul Fac Med, Dept Ophthalmol, Istanbul, Turkey

[22] Vittala Int Inst Ophthalmol, Prabha Eye Clin & Res Ctr, Bangalore, Karnataka, India

[23] LV Prasad Eye Inst, Dept Ophthalmol, Bhubaneswar, India

[24] King Khalid Eye Specialist Hosp, Dept Ophthalmol, Riyadh, Saudi Arabia

[25] Sorbonne Univ, Dept Ophthalmol, DHU SightRestore, Paris, France

[26] Univ Milan, Luigi Sacco Hosp, Dept Biomed & Clin Sci L Sacco, Eye Clin, Milan, Italy

[27] Northwestern Univ, Dept Ophthalmol, Feinberg Sch Med, Chicago, IL 60611 USA

[28] Ctr Ophthalm Specialised Care, Lausanne, Switzerland

[29] Univ Lausanne, Lausanne, Switzerland

[30] Med Univ Vienna, Ctr Ocular Inflammat & Infect OCUVAC, Laura Bassi Ctr Expertise Ctr Pathophysiol Infect, Vienna, Austria

[31] Ramon & Cajal Univ Hosp, Dept Ophthalmol, Madrid, Spain

[32] Univ Thessaly, Dept Ophthalmol, Volos, Greece

[33] PGIMER, Dept Rheumatol, Chandigarh, India

[34] PGIMER, Dept Microbiol, Chandigarh, India

[35] Univ Tubingen, Ctr Ophthalmol, Dept Ophthalmol, Tubingen, Germany

[36] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Chest & Allergy Clin, London, England

[37] UCSF Sch Med, Francis & Proctor Fdn, San Francisco, CA USA

[38] Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA 02115 USA

[39] MyungSung Christian Med Ctr, MCM Eye Unit, Addis Ababa, Ethiopia

[40] MyungSung Med Sch, Addis Ababa, Ethiopia

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2020年 / 28卷

关键词：

Tuberculosis; uveitis; visual morbidity; visual impairment; blindness; DIAGNOSIS;

D O I：

10.1080/09273948.2020.1774905

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objective Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods Multi-center retrospective cohort study. Main outcomes were VI. Results A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p< .001). Mean BCVA was worse at 12-18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

引用

页码：49 / 57

页数：9

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