Long-term protection from SARS coronavirus infection conferred by a single immunization with an attenuated VSV-based vaccine

被引:132
|
作者
Kapadia, SU
Rose, JK
Lamirande, E
Vogel, L
Subbarao, K
Roberts, A
机构
[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
[3] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
intranasal; neutralizing antibodies; protective immunity; spike;
D O I
10.1016/j.virol.2005.06.016
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Although the recent SARS coronavirus (SARS-CoV) that appeared in 2002 has now been contained, the possibility of re-emergence of SARS-CoV remains. Due to the threat of re-emergence, the overall fatality rate of similar to 10%, and the rapid dispersion of the virus via international travel, viable vaccine candidates providing protection from SARS are clearly needed. We developed an attenuated VSV recombinant (VSV-S) expressing the SARS coronavirus (SARS-CoV) spike (S) protein. In cells infected with this recombinant, S protein was synthesized, glycosylated at approximately 17 Asn residues, and transported via the Golgi to the cell surface. Mice vaccinated with VSV-S developed SARS-neutralizing antibody and were able to control a challenge with SARS-CoV performed at I month or 4 months after a single vaccination. We also demonstrated, by passive antibody transfer, that the antibody response induced by the vaccine was sufficient for controlling SARS-CoV infection. A VSV-vectored SARS vaccine could have significant advantages over other SARS vaccine candidates described to date. (c) 2005 Published by Elsevier Inc.
引用
收藏
页码:174 / 182
页数:9
相关论文
共 50 条
  • [21] Long-term persistence of anti-HAV antibody conferred by a single dose of live-attenuated hepatitis A vaccine: Results from 17-year follow-up
    Chen, Ying
    Zhao, Yu-Liang
    Hao, Zhi-Yong
    Zhang, Xin-Jiang
    Ma, Jing-Chen
    Zhang, Zhi-Yong
    Zhang, Yan-Hong
    Zhao, Gan
    Qiu, Chao
    Kilgore, Paul E.
    Wang, Song-Mei
    Wang, Xuan-Yi
    JOURNAL OF VIRAL HEPATITIS, 2021, 28 (12) : 1751 - 1755
  • [22] Mucosal immunization confers long-term protection against intragastrically established Neospora caninum infection
    Ferreirinha, Pedro
    Correia, Alexandra
    Teixeira-Coelho, Maria
    Osorio, Hugo
    Teixeira, Luzia
    Rocha, Antonio
    Vilanova, Manuel
    VACCINE, 2016, 34 (50) : 6250 - 6258
  • [23] BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine
    Perera, Dilhan J.
    Domenech, Pilar
    Babuadze, George Giorgi
    Naghibosadat, Maedeh
    Alvarez, Fernando
    Koger-Pease, Cal
    Labrie, Lydia
    Stuible, Matthew
    Durocher, Yves
    Piccirillo, Ciriaco A.
    Lametti, Andre
    Fiset, Pierre Olivier
    Elahi, Seyyed Mehdy
    Kobinger, Gary P.
    Gilbert, Renald
    Olivier, Martin
    Kozak, Robert
    Reed, Michael B.
    Ndao, Momar
    ISCIENCE, 2023, 26 (09)
  • [24] RECOMBINANT FELV VACCINE - LONG-TERM PROTECTION AND EFFECT ON COURSE AND OUTCOME OF FIV INFECTION
    HOFMANNLEHMANN, R
    HOLZNAGEL, E
    AUBERT, A
    OSSENT, P
    REINACHER, M
    LUTZ, H
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1995, 46 (1-2) : 127 - 137
  • [25] The Long-Term Serological Profile of CoronaVac Vaccine Based on Comorbidities and History of SARS-CoV-2 Infection in Indonesia
    Chilmi, Syahrul
    Kesuma, Tanti Adelia
    Wibawa, Purwa Adrianta
    Susianti, Hani
    Iskandar, Agustin
    Wulanda, Indah Adhita
    Wahono, Caesarius Singgih
    Handono, Kusworini
    JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2024, 77 (01) : 40 - 46
  • [26] A Live, Attenuated Bordetella pertussis Vaccine Provides Long-Term Protection against Virulent Challenge in a Murine Model
    Skerry, Ciaran M.
    Mahon, Bernard P.
    CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (02) : 187 - 193
  • [27] Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents
    Wong, Gary
    Audet, Jonathan
    Fernando, Lisa
    Fausther-Bovendo, Hugues
    Alimonti, Judie B.
    Kobinger, Gary P.
    Qiu, Xiangguo
    VACCINE, 2014, 32 (43) : 5722 - 5729
  • [28] Evaluation of Flathead Grey Mullets (Mugil cephalus) Immunization and Long-Term Protection against Vibrio harveyi Infection Using Three Different Vaccine Preparations
    Strem, Rosa
    Meiri-Ashkenazi, Iris
    Segal, Na'ama
    Ehrlich, Roberto
    Shashar, Nadav
    Sharon, Galit
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [29] A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox
    Iizuka, Itoe
    Ami, Yasushi
    Suzaki, Yuriko
    Nagata, Noriyo
    Fukushi, Shuetsu
    Ogata, Momoko
    Morikawa, Shigeru
    Hasegawa, Hideki
    Mizuguchi, Masashi
    Kurane, Ichiro
    Saijo, Masayuki
    JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2017, 70 (04) : 408 - 415
  • [30] Evaluation of the long-term protection conferred by an organosilicon-based disinfectant formulation against bacterial contamination of surfaces
    Le, Nguyen Nhat Thu
    Wu, Jianfeng
    Rickard, Alexander H.
    Xi, Chuanwu
    JOURNAL OF APPLIED MICROBIOLOGY, 2024, 135 (09)