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Shanghai Jiao Tong Univ, Shanghai Canc Inst,MOE Key Lab Syst Biomed,Ctr Co, Inst Syst Biomed,Joint Int Res Lab Metab & Dev Sc, Xin Hua Hosp,State Key Lab Oncogenes & Related Ge, Shanghai 200240, Peoples R China Shanghai Jiao Tong Univ, Shanghai Canc Inst,MOE Key Lab Syst Biomed,Ctr Co, Inst Syst Biomed,Joint Int Res Lab Metab & Dev Sc, Xin Hua Hosp,State Key Lab Oncogenes & Related Ge, Shanghai 200240, Peoples R China