Iodine-Mediated Oxidative Annulation by C-C Cleavage: A Domino Synthetic Approach to Quinazolinones and Benzo[4,5]imidazo[1,2-c]quinazolines

被引：5

作者：

Donthiboina, Kavitha ^{[1
]}

Mani, Geeta Sai ^{[1
]}

Shankaraiah, Nagula ^{[1
]}

Kamal, Ahmed ^{[1
,2
]}

机构：

[1] NIPER Hyderabad, Dept Med Chem, Hyderabad 500037, Andhra Pradesh, India

[2] Jamia Hamdard, SPER, New Delhi 110062, India

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 13期

关键词：

Annulation; Benzimidazo-quinazolines; C-C bond cleavage; Cleavage reactions; Copper iodide; Domino process; I-2; Quinazolinones; ONE-POT SYNTHESIS; CARBON BOND-CLEAVAGE; CONTAINING HETEROCYCLES; O-AMINOBENZAMIDES; N-HETEROCYCLES; ACTIVATION; CHEMISTRY; CONSTRUCTION; AMINES; QUINAZOLIN-4(3H)-ONES;

D O I：

10.1002/slct.202000682

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile iodine-mediated unprecedented C-C cleavage by employing CuI has been established towards the synthesis of quinazolin-4(3H)-ones and benzo[4,5]imidazo[1,2-c]quinazolines. This protocol involves peroxide free synthetic approach for the stable C-C bond cleavage followed by oxidative annulation to develop a library of fused N-heterocyclic molecules.

引用

页码：3923 / 3928

页数：6

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