Non-T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation from a family donor based on fetomaternal microchimerism in pediatric hematologic malignancies

被引：8
|
作者：
Ishida, H
Morimoto, A
Yoshihara, T
Kuroda, H
Mori, K
Fujii, N
Tamura, S
Hibi, S
Todo, S
Maruya, E
Imashuku, S
机构：
[1] Matsushita Mem Hosp, Div Pediat, Moriguchi, Osaka 5708540, Japan
[2] Kyoto Prefectural Univ Med, Dept Pediat, Kyoto 602, Japan
[3] Kyoto City Hosp, Div Pediat, Kyoto, Japan
[4] HLA Lab, Kyoto, Japan
[5] Kyoto City Inst Hlth & Environm Sci, Kyoto, Japan
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2004年 / 26卷 / 01期
关键词：
hematopoietic stem cell transplantation; fetomatemal; microchimerism; HLA-haploidentical donor; non-T-cell; -depletion; graft-versus-host disease; bone marrow transplantation;
D O I：
10.1097/00043426-200401000-00020
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Based on recent fetomatemal microchimerism/tolerance theory, two children with acute lymphoblastic leukemia underwent non-T-cell-depleted hematopoietic stem cell transplants (SCT) from haploidentical HLA 2 loci-mismatched family donors (one from a sibling, one from the mother). Engraftment was achieved in two patients. In two recipients, acute graft-versus-host disease was limited to grade II or less, and no chronic graft-versus-host disease developed. Both of these patients have maintained complete remission for more than 8 months post-SCT. Non-T-cell-depleted SCT from haploidentical HLA 2 loci-mismatched family donors seems feasible if microchimerism is detectable.
引用
收藏
页码：68 / 71
页数：4
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