Effect of nimodipine on cell calcium concentration and platelet aggregation in patients with ischemic stroke

被引：0
|
作者：
Pryanikova, NA
Dukhanin, AS
Stakhovskaya, LV
Chekneva, NS
机构：
[1] RUSSIAN STATE MED UNIV,DEPT MOL PHARMACOL,MOSCOW 117437,RUSSIA
[2] RUSSIAN STATE MED UNIV,DEPT NEUROL & NEUROSURG 2,MOSCOW 117437,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1996年 / 121卷 / 03期
关键词：
calcium channel blockers; ischemic stroke; platelets;
D O I：
10.1007/BF02446774
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The rate of spontaneous platelet aggregation is 1.5-2-fold increased in patients with ischemic stroke in comparison with control values. Monotherapy with nimodipine lowers parameters of spontaneous platelet aggregation virtually to normal values. Nimodipine inhibits ADP-induced aggregation but does not affect the ADP affinity of platelet receptors. Experiments with a Fura 2-AM fluorescent probe show that the basal calcium level in platelets from patients with ischemic stroke reliably surpassed that in healthy donors. Nimodipine inhibits the ADP-induced rise of the cell calcium level.
引用
收藏
页码：291 / 293
页数：3
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