Efficient induction of protective antimalaria immunity by recombinant adenovirus

被引：37
|
作者：
Rodrigues, EG
Zavala, F
Nussenzweig, RS
Wilson, JM
Tsuji, M [1 ]
机构：
[1] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA
[2] Univ Penn, Inst Human Gene Therapy, Dept Mol & Cellular Engn, Philadelphia, PA 19104 USA
来源：
VACCINE | 1998年 / 16卷 / 19期
关键词：
malaria; adenovirus; protection;
D O I：
10.1016/S0264-410X(98)00181-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immunogenicity of a previously constructed replication- defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection. (C) 1998 Elsevier science Ltd. All rights reserved.
引用
收藏
页码：1812 / 1817
页数：6
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