Twelve Years of Neandertal Genetic Discoveries: State-of-the-Art and Future Challenges

被引：0

作者：

Orlando, Ludovic ^{[1
]}

Haenni, Catherine ^{[2
]}

机构：

[1] Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark

[2] Univ Lyon, CNRS, Ecole Normale Super Lyon, UMR 5242, Lyon, France

来源：

CONTINUITY AND DISCONTINUITY IN THE PEOPLING OF EUROPE: ONE HUNDRED FIFTY YEARS OF NEANDERTHAL STUDY | 2011年

关键词：

Ancient DNA; mtDNA; Comparative genomics; Pyrosequencing; 2-round Multiplex; SNP; ANCIENT MITOCHONDRIAL-DNA; LATE PLEISTOCENE; MODERN HUMANS; MOLECULAR EVOLUTION; SEQUENCES; SELECTION; MTDNA; PATTERNS; GENOME; REGION;

D O I：

10.1007/978-94-007-0492-3_21

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The first mitochondrial DNA sequence from a Neandertal specimen was recovered in 1997. Now the completion of the whole Neandertal genome has been announced to be completed in the forthcoming months. About one million nucleotides of nuclear DNA have already been sequenced and so far 15 Neandertal specimens have delivered authentic mitochondrial sequences. This information has helped us to better understand the evolution of the Neandertal gene pool over space and time and to address the long-standing question of possible admixture with their modem human relatives. This chapter reviews current knowledge on NeandertalDNA sequences and presents future challenges related to Neandertal genomics.

引用

页码：223 / +

页数：5

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