Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases

被引：48
|
作者：
Angeli, Andrea [1 ]
Ferraroni, Marta [2 ]
Supuran, Claudiu T. [1 ]
机构：
[1] Univ Florence, NEUROFARBA Dept, Sez Sci Farmaceut, Via Ugo Schiff 6, I-50019 Florence, Italy
[2] Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 13, I-50019 Florence, Italy
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2018年 / 9卷 / 10期
关键词：
Carbonic anhydrase; famotidine; Helicobacter pylori; inhibitor; metalloenzymes; SULFONAMIDE INHIBITION; IN-VITRO; RANITIDINE; OMEPRAZOLE;
D O I：
10.1021/acsmedchemlett.8b00334
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and Helicobacter pylori CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action.
引用
收藏
页码：1035 / 1038
页数：7
相关论文
共 50 条
  • [21] HELICOBACTER-PYLORI INDUCED AMMONIA INHIBITS PHAGOCYTOSIS BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES
    MAYO, K
    HELD, M
    WADSTROM, T
    MEGRAUD, F
    GASTROENTEROLOGY, 1993, 104 (04) : A739 - A739
  • [22] The dopamine D2 receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms
    Angeli, Andrea
    Ferraroni, Marta
    Capasso, Clemente
    Supuran, Claudiu T.
    CHEMISTRY-AN ASIAN JOURNAL, 2024, 19 (08)
  • [23] SULGLYCOTIDE INHIBITS DEGRADATION OF HUMAN GASTRIC MUCUS BY HELICOBACTER-PYLORI PROTEASE AND LIPASES
    PIOTROWSKI, J
    CZAJKOWSKI, A
    YOTSUMOTO, F
    SLOMIANY, A
    SLOMIANY, BL
    GASTROENTEROLOGY, 1993, 104 (04) : A171 - A171
  • [24] Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells
    Oswald-Richter, Kyra
    Torres, Victor J.
    Sundrud, Mark S.
    VanCompernolle, Scott E.
    Cover, Timothy L.
    Unutmaz, Derya
    JOURNAL OF VIROLOGY, 2006, 80 (23) : 11767 - 11775
  • [25] THE NOVEL ANTIULCER AGENT ECABET SODIUM (TA-2711) ERADICATES HELICOBACTER-PYLORI COLONIZING ON THE GASTRIC-MUCOSA OF JAPANESE MONKEYS
    FUKUDA, Y
    MIZUTA, T
    YAMAMOTO, I
    TAMURA, K
    SHIMOYAMA, T
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1994, 29 (11) : 1055 - 1056
  • [26] Solanum torvum inhibits Helicobacter pylori growth and mediates apoptosis in human gastric epithelial cells
    Hsu, Yuan-Man
    Weng, Jing-Ru
    Huang, Tsurng-Juhn
    Lai, Chih-Ho
    Sui, Chiu-Hsiang
    Chou, Chang-Hung
    ONCOLOGY REPORTS, 2010, 23 (05) : 1401 - 1405
  • [27] An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach
    Wittschier, N.
    Faller, G.
    Hensel, A.
    PHYTOMEDICINE, 2007, 14 (04) : 285 - 288
  • [28] Pelargonium sidoides extract EPs 7630 inhibits adhesion of Helicobacter pylori to human gastric mucosa
    Wittschier, N.
    Faller, G.
    Hensel, A.
    PLANTA MEDICA, 2006, 72 (11) : 1053 - 1053
  • [29] REBAMIPIDE, A NOVEL ANTIULCER AGENT, ATTENUATES HELICOBACTER-PYLORI INDUCED GASTRIC-MUCOSAL CELL INJURY ASSOCIATED WITH NEUTROPHIL-DERIVED OXIDANTS
    SUZUKI, M
    MIURA, S
    MORI, M
    KAI, A
    SUZUKI, H
    FUKUMURA, D
    SUEMATSU, M
    TSUCHIYA, M
    GUT, 1994, 35 (10) : 1375 - 1378
  • [30] Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa
    Saha, Arindam
    Hammond, Charles E.
    Beeson, Craig
    Peek, Richard M., Jr.
    Smolka, Adam J.
    GUT, 2010, 59 (07) : 874 - 881
12345