Impact of Sensor-Augmented Pump Therapy with Predictive Low-Glucose Suspend Function on Glycemic Control and Patient Satisfaction in Adults and Children with Type 1 Diabetes

Aims: The aim was to evaluate the effectiveness of sensor-augmented pump therapy with predictive low-glucose suspend function (SAP-PLGS) in real-world use in children and adults with type 1 diabetes (T1D). Methods: Patients with T1D treated with the MiniMed 640G((R)) pump with PLGS function at three referral hospitals were retrospectively evaluated. Hb(A1c) at baseline and at 6, 12, 18, and 24 months was analyzed. Two weeks of data from pumps, sensors, and/or glucose meters were downloaded. Patients completed satisfaction questionnaires at the last follow-up visit. Results: A total of 162 patients were included. Mean age was 3217 years, 28% were (n=46) children, and 29% (n=47) were with a history of severe hypoglycemia. Median follow-up was 12 months (6-18). Hb(A1c) was reduced from 55 +/- 9 to 54 +/- 8mmol/mol (7.2%+/- 0.8% to 7.1%+/- 0.7%) at 12 months (P<0.03, n=100). In patients with suboptimal control, there was a reduction in Hb(A1c) from 66%+/- 7% to 61 +/- 10mmol/mol (8.2%+/- 0.6% to 7.7%+/- 0.9%) at the end of follow-up (n=26, P<0.01). Three percent (n=5) of the patients experienced severe hypoglycemia during follow-up. A reduction in the percentage of self-monitoring of blood glucose values <70mg/dL was achieved (10%+/- 7% to 6%+/- 5%, P=0.001, n=144). Time in range 70-180mg/dL was 67%+/- 13% at the end of follow-up and predictors of a higher time in range were identified. The use of sensors was high (86%) and 73% of the patients showed high satisfaction. In patients using sensors at baseline (n=54), the time spent at <54 and <70mg/dL was reduced. Conclusion: SAP-PLGS reduces hypoglycemia frequency while maintaining glycemic control in adults and children under real-life conditions.