Crossover study comparing bioavailability of a capsule formulation of the glucagon receptor antagonist LGD-6972 to an oral solution formulation in healthy subjects

被引：0
|
作者：
Pipkin, J. D. [1 ]
Vajda, E. [1 ]
Biernat, L. [2 ]
Klein, D. J. [2 ]
Li, Y. -X. [2 ]
Zangmeister, M. [2 ]
Zhou, R. [2 ]
Zhi, L. [1 ]
Marschke, K. [1 ]
机构：
[1] Ligand Pharmaceut Inc, San Diego, CA USA
[2] Medpace Inc, Cincinnati, OH USA
来源：
DIABETOLOGIA | 2017年 / 60卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
863
引用
收藏
页码：S399 / S400
页数：2
相关论文
共 50 条
  • [31] Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant
    Klaus Francke
    Niladri Chattopadhyay
    Stefan Klein
    Antje Rottmann
    Dennis Krickau
    Jeroen van de Wetering
    Christian Friedrich
    European Journal of Drug Metabolism and Pharmacokinetics, 2023, 48 : 75 - 87
  • [32] Pharmacokinetics and bioequivalence of a molnupiravir tablet formulation compared with the molnupiravir capsule formulation in healthy adult participants-a randomized, open-label, three-period, crossover study
    Fiore, Julie L.
    Jin, Yoon
    Heimbach, Tycho
    Patel, Shruti R.
    Zhao, Tian
    Matthews, Catherine Z.
    Pagnussat, Sandra
    Maas, Brian M.
    Cheng, Mickie H.
    Stoch, S. Aubrey
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2025, 69 (03)
  • [33] A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation
    van Rossem, Koen
    Lowe, Jenny A.
    CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS, 2013, 5 : 23 - 31
  • [34] A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258)
    Infante, Jeffrey R.
    Ramanathan, Ramesh K.
    George, Daniel
    Tan, Eugene
    Quinlan, Michelle
    Liu, Angela
    Scott, Jeffrey W.
    Sharma, Sunil
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2015, 75 (04) : 729 - 737
  • [35] A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258)
    Jeffrey R. Infante
    Ramesh K. Ramanathan
    Daniel George
    Eugene Tan
    Michelle Quinlan
    Angela Liu
    Jeffrey W. Scott
    Sunil Sharma
    Cancer Chemotherapy and Pharmacology, 2015, 75 : 729 - 737
  • [36] Relative Oral Bioavailability of an Abuse-deterrent, Extended-release Formulation of Morphine Versus Extended-release Morphine: A 2-period, Single-dose, Randomized Crossover Study in Healthy Subjects
    Kinzler, Eric R.
    Pantaleon, Carmela
    Aigner, Stefan
    CLINICAL THERAPEUTICS, 2018, 40 (08) : 1357 - 1365
  • [37] Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS)
    Moedinger, Yvonne
    Knaub, Katharina
    Dharsono, Tanita
    Wacker, Roland
    Meyrat, Remo
    Land, M. Hunter
    Petraglia, Anthony L.
    Schoen, Christiane
    MOLECULES, 2022, 27 (09):
  • [38] A Phase 1 Study to Evaluate the Bioavailability and Food Effect of 2 Solid-Dispersion Formulations of the TRPV1 Antagonist ABT-102, Relative to the Oral Solution Formulation, in Healthy Human Volunteers
    Othman, Ahmed A.
    Cheskin, Howard
    Locke, Charles
    Nothaft, Wolfram
    Dutta, Sandeep
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2012, 1 (01): : 24 - 31
  • [39] A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects
    Knaub, Katharina
    Sartorius, Tina
    Dharsono, Tanita
    Wacker, Roland
    Wilhelm, Manfred
    Schoen, Christiane
    MOLECULES, 2019, 24 (16):
  • [40] A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects
    Lee, Hae Won
    Kang, Woo Youl
    Park, Ji Seo
    Lee, Jae Hwa
    Park, Jin Ju
    Gwon, Mi-Ri
    Yoon, Young-Ran
    Seong, Sook Jin
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 19 : 97 - 110
12345