Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia

被引：0
|
作者：
Li, Shasha [1 ]
Yang, Yonghong [1 ]
Gao, Qiang [1 ]
He, Jing [1 ]
He, Chengqi [1 ]
机构：
[1] Sichuan Univ, W China Hosp, Key Lab Rehabil Med Sichuan Prov, Dept Rehabil Med, Chengdu 610041, Sichuan Prov, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2010年 / 5卷 / 19期
关键词：
low frequency electrical stimulation; angiopoietin 1 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains; middle cerebral artery occlusion model; dysphagia; ARTERY OCCLUSION; MOTOR CORTEX; STROKE; RECOVERY; REORGANIZATION; PREDICTORS; MECHANISMS; DYSPHAGIA; RISK; TIE2;
D O I：
10.3969/j.issn.1673-5374.2010.19.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Angiopoietin 1/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (Tie 2) is a newly discovered signaling pathway of angiogenesis Angiogenesis benefits recovery of neurological functions such as swallowing In the present study, a rat model of dysphagia following stroke was induced by middle cerebral artery occlusion to investigate the influence of low frequency electrical stimulus with bidirectional square waves and triangular waves on angiopoietin 1/Tie 2 mRNA expression Reverse transcription polymerase chain reaction results showed that low frequency electrical stimulus significantly improved the neurological scores of the model rats and increased angiopoietin 1/Tie 2 mRNA expression This demonstrates that low frequency electrical stimulation can ameliorate neurological function in rats with focal brain ischemia potentially through regulation of angiopoietin 1/Tie 2 expression in the angiogenesis pathway
引用
收藏
页码：1470 / 1474
页数：5
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