Covalently bonded polysaccharide derivatives as chiral stationary phases in high-performance liquid chromatography

被引：188
|
作者：
Franco, P
Senso, A
Oliveros, L
Minguillón, C
机构：
[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, E-08028 Barcelona, Spain
[2] Conservatoire Natl Arts & Metiers, Lab Chim Gen, F-75141 Paris 03, France
来源：
JOURNAL OF CHROMATOGRAPHY A | 2001年 / 906卷 / 1-2期
关键词：
reviews; chiral stationary phases; LC; enantiomer separations; polysaccharide derivatives; cellulose; amylose; chitosan;
D O I：
10.1016/S0021-9673(00)00531-8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Polysaccharide derivatives have been extensively used as chromatographic chiral selectors in chiral stationary phases (CSPs) for the separation of enantiomers by HPLC. When coated onto a silica matrix, they represent nowadays one of the most popular type of CSPs. However, they are only compatible with a limited choice of solvents. The main drawback of these CSPs is related to the solubility of the chiral selector in a number of solvents, which Limits their applicability. The different attempts which have been described up to now to overcome this problem by covalently fixing the chiral selector to a matrix are reviewed in this paper. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：155 / 170
页数：16
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