Regioselective Monoarylation of 2-Phenylbenzimidazole via Ruthenium-Catalyzed C-H Bond Functionalization

被引：14

作者：

Kobayashi, Yasuyuki ^{[1
]}

Kashiwa, Mitsuhiro ^{[1
]}

Sonoda, Motohiro ^{[1
]}

Kirihata, Mitsunori ^{[1
]}

Tanimori, Shinji ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Dept Biosci & Informat, Naka Ku, Sakai, Osaka 5998531, Japan

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 23期

关键词：

C-H bond activation; benzimidazole; arylation; ruthenium catalyst; directing group; DIRECT ORTHO ARYLATION; BENZIMIDAZOLE DERIVATIVES; ALKENYLATION; INHIBITORS; DESIGN;

D O I：

10.1055/s-0034-1379013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly regioselective monoarylation of 1-methyl-2-phenyl-1H-benzimidazole has been demonstrated. The reaction of 1-methyl-2-phenyl-1H-benzimidazole with 4-iodoanisole provided 2-(4-methoxybiphenyl-2-yl)-1-methyl-1H-benzimidazole as the sole product in 96% isolated yield in the presence of [RuCl2(p-cymene)](2) and triphenylphosphine as precatalysts. A series of novel 2-(biphenyl-2-yl)benzimidazoles have been synthesized in good to excellent yields.

引用

页码：3185 / 3190

页数：6

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