Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli

被引：63

作者：

Tompkins, JD ^{[1
]}

Nelson, JL ^{[1
]}

Hazel, JC ^{[1
]}

Leugers, SL ^{[1
]}

Stumpf, JD ^{[1
]}

Foster, PL ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 11期

关键词：

D O I：

10.1128/JB.185.11.3469-3472.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.

引用

页码：3469 / 3472

页数：4

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