5′ Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents

被引：2
|
作者：
Thakur, Abhishek [1 ]
Dan, Nirnoy [1 ]
Bhakat, Soumendranath [2 ]
Jayaprakash, Venkatesan [1 ]
Banerjee, Sugato [1 ]
机构：
[1] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Mesra Ranchi 835215, Jharkhand, India
[2] Kwazulu Natal Univ, Durban, South Africa
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 08期
关键词：
AMPK; anti-cancer; diabetes; natural; synthetic; STRUCTURAL BASIS; CELL-METABOLISM; AMPK ACTIVATORS; GLUCOSE-UPTAKE; CANCER; APOPTOSIS; BETA; MECHANISM; GROWTH; INHIBITION;
D O I：
10.2174/1871520616666160211124240
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5' Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
引用
收藏
页码：961 / 972
页数：12
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