Two New Nitrogenous Compounds from the Seeds of Brassica napus

被引：2

作者：

Jing, Wenguang ^{[1
]}

Zhao, Xiaoliang ^{[2
]}

Liu, An ^{[2
]}

Wei, Feng ^{[1
]}

Ma, Shuangcheng ^{[1
]}

机构：

[1] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China

[2] China Acad Chinese Med Sci, Beijing 100700, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 03期

关键词：

nitrogenous compounds; rapeseed Brassica napus L; alkaloid; antineuroinflammatory activity;

D O I：

10.1007/s10600-022-03719-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new nitrogenous compounds identified as (2S)-2-sinapoyl-4-pentenenitrile (1) and brassicalkaloid A (2) have been isolated from the seed of Brassica napus L. along with four known alkaloids (3-6). The chemical structures of the new compounds were determined by detailed analysis of spectral data including 1D and 2D NMR spectroscopy. The antineuroinflammatory activity of the isolated compounds was investigated. Brassicalkaloid A (2) and coixspirolactam C (5) were found to exhibit potent activities with IC50 values of 36.6 +/- 0.04 mu M and 51.0 +/- 0.01 mu M.

引用

页码：501 / 505

页数：5

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