Impact of Six-week Viral Load on Mortality in HIV-infected Zimbabwean Infants

被引：6

作者：

Mutasa, Kuda ^{[1
]}

Ntozini, Robert ^{[1
]}

Prendergast, Andrew ^{[1
,2
,3
]}

Iliff, Peter ^{[1
]}

Rukobo, Sandra ^{[1
]}

Moulton, Lawrence H. ^{[3
]}

Ward, Brian J. ^{[4
]}

Humphrey, Jean H. ^{[1
,2
]}

机构：

[1] Zvitambo Project, Harare, Zimbabwe

[2] Univ London, Ctr Paediat, Blizard Inst, London WC1E 7HU, England

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA

[4] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ, Canada

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 09期

关键词：

HIV; infants; viral load; mortality; disease progression; DISEASE PROGRESSION; TRANSMISSION; ASSOCIATION; THERAPY; RNA;

D O I：

10.1097/INF.0b013e318266aac2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load >= 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

引用

页码：948 / 950

页数：3

共 50 条

[41] CHARACTERIZATION OF PROTEINURIA IN HIV-INFECTED INFANTS
ABITBOL, C
STRAUSS, J
ZILLERUELO, G
MONTANE, B
ROJAS, E
PEDIATRIC RESEARCH, 1994, 35 (04) : A359 - A359
[42] HYPOGAMMAGLOBULINEMIA IN HIV-INFECTED INFANTS - REPLY
WONG, JT
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (05): : 322 - 322
[43] Shedding of Oral Poliovirus Vaccine (OPV) by HIV-Infected and - Uninfected Mothers of OPV-Vaccinated Zimbabwean Infants
Holubar, Marisa
Troy, Stephanie B.
Nathoo, Kusum
Stranix-Chibanda, Lynda
Musingwini, Georgina
Srinivas, Nivedita
Huang, ChunHong
Junn, Alexandra
Halpern, Meira S.
Maldonado, Yvonne A.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2017, 6 (01) : 105 - 108
[44] Routine viral load monitoring in HIV-infected infants and children in low- and middle-income countries: challenges and opportunities
Arpadi, Stephen M.
Shiau, Stephanie
De Gusmao, Eduarda Pimentel
Violari, Avy
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2017, 20 : 32 - 36
[45] Partner HIV Serostatus Impacts Viral Load, Genital HIV Shedding, and Immune Activation in HIV-Infected Individuals
Jaumdally, Shameem Z.
Liebenberg, Lenine J. P.
Gumbi, Pam P.
Little, Francesca
Jaspan, Heather B.
Gamieldien, Hoyam
Tiemessen, Caroline T.
Coetzee, David
Martin, Darren P.
Williamson, Carolyn
Williamson, Anna-Lise
Passmore, Jo-Ann S.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2019, 82 (01) : 51 - 60
[46] Extensive antiretroviral therapy resistance in an HIV-infected Zimbabwean patient in the UK
Foley, E
Watson-Jones, D
Loveday, C
AIDS, 2003, 17 (16) : 2404 - 2405
[47] Time to Viral Suppression in Perinatally HIV-Infected Infants Depends on the Viral Load and CD4 T-Cell Percentage at the Start of Treatment
Schroter, Juliane
Anelone, Anet J. N.
Yates, Andrew J.
de Boer, Rob J.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2020, 83 (05) : 522 - 529
[48] Impact of tuberculosis preventive therapy on tuberculosis and mortality in HIV-infected children
Gray, Diane M.
Zar, Heather
Cotton, Mark
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (01):
[49] Mortality in HIV-infected and uninfected children of HIV-infected and uninfected mothers in rural Uganda
Brahmbhatt, H
Kigozi, G
Wabwire-Mangen, F
Serwadda, D
Lutalo, T
Nalugoda, F
Sewankambo, N
Kiduggavu, M
Wawer, M
Gray, R
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 41 (04) : 504 - 508
[50] Prevalence of persistent asymptomatic proteinuria in HIV-infected outpatients and lack of correlation with viral load
Crowley, ST
Cantwell, B
Abu-Alfa, A
Rigsby, MO
CLINICAL NEPHROLOGY, 2001, 55 (01) : 1 - 6

← 1 2 3 4 5 →