Impact of Six-week Viral Load on Mortality in HIV-infected Zimbabwean Infants

被引：6

作者：

Mutasa, Kuda ^{[1
]}

Ntozini, Robert ^{[1
]}

Prendergast, Andrew ^{[1
,2
,3
]}

Iliff, Peter ^{[1
]}

Rukobo, Sandra ^{[1
]}

Moulton, Lawrence H. ^{[3
]}

Ward, Brian J. ^{[4
]}

Humphrey, Jean H. ^{[1
,2
]}

机构：

[1] Zvitambo Project, Harare, Zimbabwe

[2] Univ London, Ctr Paediat, Blizard Inst, London WC1E 7HU, England

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA

[4] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ, Canada

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 09期

关键词：

HIV; infants; viral load; mortality; disease progression; DISEASE PROGRESSION; TRANSMISSION; ASSOCIATION; THERAPY; RNA;

D O I：

10.1097/INF.0b013e318266aac2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load >= 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

引用

页码：948 / 950

页数：3

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