Boron neutron capture in prostate cancer cells

被引：17
|
作者：
Yasui, Linda [1 ]
Kroc, Thomas [3 ]
Gladden, Samantha [1 ]
Andorf, Christine [4 ]
Bux, Sajit [2 ,5 ]
Hosmane, Narayan [2 ]
机构：
[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA
[2] No Illinois Univ, Dept Chem & Biochem, De Kalb, IL 60115 USA
[3] Fermilab Natl Accelerator Lab, Batavia, IL 60510 USA
[4] No Illinois Univ, Inst Neutron, Batavia, IL USA
[5] Kishwaukee Community Hosp, De Kalb, IL USA
来源：
APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 01期
基金：
美国国家科学基金会;
关键词：
Boron neutron capture; BPA; Cell survival; IN-VITRO; THERAPY; RADIATION; BOOST;
D O I：
10.1016/j.apradiso.2011.07.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A modified enhanced thermal neutron beam (METNB) assembly at Fermilab was used to irradiate borylphenylalanine (BPA) treated human prostate cancer cells, DU 145. Acceptable cellular uptake levels of BPA and no BPA cytotoxicity were observed. In the absence of BPA, the relative biological effectiveness (RBE) of the METNB was determined to be 2.3-4.8 times greater than gamma rays. An additional 1.2 or 1.4 fold relative enhancement from boron neutron capture (REBNC) was observed for METNB irradiated DU 145 cells treated with 4.9 or 12 mM BPA, respectively. The additional cell killing of the BPA loaded DU 145 cells by the METNB at Fermilab is evidence for a BNC enhanced cell killing. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6 / 12
页数：7
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