Steroidal glycosides from the bulbs of Allium jesdianum

被引：50
|
作者：
Mimaki, Y [1 ]
Kuroda, M [1 ]
Fukasawa, T [1 ]
Sashida, Y [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期
关键词：
D O I：
10.1021/np980346b
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical analysis of the fresh bulbs of Allium jesdianum yielded four steroidal glycosides, (22S)-cholest-5-ene-1 beta, 3 beta,16 beta,22-tetrol 1,16- di-O-beta-D-glucopyranoside (1), (22S)-cholest-5-ene-1 beta,3 beta,16 beta,22-tetrol 1-O-alpha-L-rhamnopyranosyl 16-O-beta-D-glucopyranoside (2), (25R)-5 alpha-spirostane-2 alpha,3 beta-diol 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside} (F-gitonin) (3), and (25R)-5 alpha-spirostane-2 alpha,3 beta,6 alpha-triol 3-O-{O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside} (4). Compound 2 is a new natural product, and 4 is a new spirostanol saponin. Compound 3 was found to exhibit cytostatic and cytotoxic activities against several malignant tumor cells.
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页码：194 / 197
页数：4
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