Copper-catalyzed aerobic cascade reaction for the conversion of 3,4-dihydropyrimidine-2(1H)-thiones to arylthiopyrimidines

被引：12

作者：

Lee, Ok Suk ^{[1
]}

Lee, HyunKyung ^{[1
]}

Kim, Hyejee ^{[1
]}

Shin, Hyunik ^{[2
]}

Sohn, Jeong-Hun ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Nat Sci, Dept Chem, Taejon 305764, South Korea

[2] Yonsung Fine Chem R&D Ctr, Suwon 443380, South Korea

来源：

TETRAHEDRON | 2015年 / 71卷 / 19期

关键词：

Copper catalysis; Aerobic cascade reaction; C-S coupling; Oxidative dehydrogenation; Pyrimidine; COUPLING REACTIONS; OXIDATIVE DEHYDROGENATION; C-S; DEEP DESULFURIZATION; ARYL HALIDES; SULFUR; DIHYDROPYRIMIDINONES; NUCLEOPHILES; ARYLATION; ACCESS;

D O I：

10.1016/j.tet.2015.03.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described is a copper-catalyzed cascade reaction method for the conversion of 3,4-dihydropyrimidine-2(1H)-thiones to arylthiopyrimidines, likely proceeded via C-S cross-coupling and oxidative dehydrogenation under aerobic conditions. The reaction method proceeded efficiently with a wide range of the dihydropyrimidinethione substrates and aryl iodides as coupling partners. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2936 / 2944

页数：9

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