Ligand- and base-free copper(II)-catalyzed C-N bond formation: Cross-coupling reactions of organoboron compounds with aliphatic amines and anilines

被引：214
|
作者：
Quach, TD [1 ]
Batey, RA [1 ]
机构：
[1] Univ Toronto, Dept Chem, Daven Res Labs, Toronto, ON M5S 3H6, Canada
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 23期
关键词：
D O I：
10.1021/ol035681s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ligandless and base-free Cu-catalyzed protocol for the cross-coupling of arylboronic acids and potassium aryltrifluoroborate salts with primary and secondary aliphatic amines and anilines is described. The process utilizes catalytic copper(II) acetate monohydrate and 4 Angstrom molecular sieves in dichloromethane at slightly elevated temperatures under an atmosphere of oxygen. A broad range of functional groups are tolerated on both of the cross-coupling partners.
引用
收藏
页码：4397 / 4400
页数：4
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