Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

被引：139

作者：

Geurts, Lucie ^{[1
]}

Everard, Amandine ^{[1
]}

Van Hul, Matthias ^{[1
]}

Essaghir, Ahmed ^{[2
]}

Duparc, Thibaut ^{[1
]}

Matamoros, Sebastien ^{[1
]}

Plovier, Hubert ^{[1
]}

Castel, Julien ^{[3
]}

Denis, Raphael G. P. ^{[3
]}

Bergiers, Marie ^{[1
]}

Druart, Celine ^{[1
]}

Alhouayek, Mireille ^{[4
]}

Delzenne, Nathalie M. ^{[1
]}

Muccioli, Giulio G. ^{[4
]}

Demoulin, Jean-Baptiste ^{[2
]}

Luquet, Serge ^{[3
]}

Cani, Patrice D. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & BIOtechnol, Metab & Nutr Res Grp, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Duve Inst, B-1200 Brussels, Belgium

[3] Univ Paris Diderot, CNRS, BFA, Sorbonne Paris Cite,UMR8251, F-75205 Paris, France

[4] Catholic Univ Louvain, Louvain Drug Res Inst, Bioanalysis & Pharmacol Bioact Lipids Res Grp, B-1200 Brussels, Belgium

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

欧洲研究理事会;

关键词：

INDUCED INSULIN-RESISTANCE; ENDOCANNABINOID SYSTEM; GLUCOSE-METABOLISM; N-ACYLPHOSPHATIDYLETHANOLAMINE; CANNABINOID RECEPTOR; FOOD-INTAKE; OBESE MICE; INFLAMMATION; ANANDAMIDE; GENE;

D O I：

10.1038/ncomms7495

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obesity, glucose intolerance, adipose tissue inflammation and altered lipid metabolism. We report that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state. Our results indicate that these alterations are mediated by a shift in gut microbiota composition that can partially transfer the phenotype to germ-free mice. Together, our findings uncover a role of adipose tissue NAPE-PLD on whole-body metabolism and provide support for targeting NAPE-PLD-derived bioactive lipids to treat obesity and related metabolic disorders.

引用

页数：15

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