Rare and transient anti-D antibody response in D- liver transplant recipients transfused with D+ red blood cells

被引：9

作者：

des Roziers, N. Burin ^{[1
]}

Ibanez, C. ^{[1
]}

Samuel, D. ^{[2
]}

Francoz, C. ^{[3
]}

Idri, S. ^{[1
]}

Francois, A. ^{[1
]}

Mortelecque, R. ^{[1
]}

Bierling, P. ^{[1
,4
]}

Pirenne, F. ^{[1
,4
]}

机构：

[1] Etab Francais Sang Ile France, Villejuif, France

[2] Hop Paul Brousse, Ctr Hepatobiliaire, Villejuif, France

[3] Hop Beaujon, Serv Hepatol & Reanimat Hepatodigest, Clichy, France

[4] Inst Mondor, Lab Excellence, Inserm,Equipe Transfus & Malad Globule Rouge 2, U955,GRex, Creteil, France

来源：

VOX SANGUINIS | 2016年 / 111卷 / 01期

关键词：

antibody formation; blood transfusion; haemolysis; immunosuppression; liver transplantation; Rh-Hr blood group system; ALLOIMMUNIZATION; HEART;

D O I：

10.1111/vox.12392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A retrospective analysis was conducted on 20 D- liver transplant (LT) recipients transfused with D+ RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-treated RBCs at 10 and 11 days without any sign of immune haemolysis. Antibodies became quickly undetectable. These data suggest an unusual pattern of alloimmunization in LT recipients with rapid, weak and transient antibody response and support the safety of transfusing D+ RBCs in most of D- patients during LT surgery.

引用

页码：107 / 110

页数：4

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