mRNA-based therapeutics-Advances and perspectives

被引：55
|
作者：
Sergeeva, O. V. [1 ,2 ]
Koteliansky, V. E. [1 ,2 ]
Zatsepin, T. S. [1 ,2 ,3 ]
机构：
[1] Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia
[2] Skolkovo Inst Sci & Technol, Skolkovo Innovat Ctr, 3 Nobel Str, Moscow 143026, Russia
[3] Cent Res Inst Epidemiol, Fed Serv Customers Rights Protect & Human Well Be, Moscow 111123, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2016年 / 81卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
DOUBLE-STRANDED-RNA; TRANSFECTED DENDRITIC CELLS; PROSTATE-CANCER PATIENTS; DELIVERY IN-VIVO; LIPID NANOPARTICLES; TRANSLATIONAL-EFFICIENCY; NONVIRAL DELIVERY; MAMMALIAN-CELLS; INNATE IMMUNITY; GENE DELIVERY;
D O I：
10.1134/S0006297916070075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.
引用
收藏
页码：709 / 722
页数：14
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