mRNA-based therapeutics-Advances and perspectives

被引：55
|
作者：
Sergeeva, O. V. [1 ,2 ]
Koteliansky, V. E. [1 ,2 ]
Zatsepin, T. S. [1 ,2 ,3 ]
机构：
[1] Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia
[2] Skolkovo Inst Sci & Technol, Skolkovo Innovat Ctr, 3 Nobel Str, Moscow 143026, Russia
[3] Cent Res Inst Epidemiol, Fed Serv Customers Rights Protect & Human Well Be, Moscow 111123, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2016年 / 81卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
DOUBLE-STRANDED-RNA; TRANSFECTED DENDRITIC CELLS; PROSTATE-CANCER PATIENTS; DELIVERY IN-VIVO; LIPID NANOPARTICLES; TRANSLATIONAL-EFFICIENCY; NONVIRAL DELIVERY; MAMMALIAN-CELLS; INNATE IMMUNITY; GENE DELIVERY;
D O I：
10.1134/S0006297916070075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.
引用
收藏
页码：709 / 722
页数：14
相关论文
共 50 条
  • [1] mRNA-based therapeutics–Advances and perspectives
    O. V. Sergeeva
    V. E. Koteliansky
    T. S. Zatsepin
    Biochemistry (Moscow), 2016, 81 : 709 - 722
  • [2] mRNA-based cancer therapeutics
    Liu, Chuang
    Shi, Qiangqiang
    Huang, Xiangang
    Koo, Seyoung
    Kong, Na
    Tao, Wei
    NATURE REVIEWS CANCER, 2023, 23 (08) : 526 - 543
  • [3] mRNA-based cancer therapeutics
    Chuang Liu
    Qiangqiang Shi
    Xiangang Huang
    Seyoung Koo
    Na Kong
    Wei Tao
    Nature Reviews Cancer, 2023, 23 : 526 - 543
  • [4] Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
    Yang, Lizhi
    Li, Shuo
    Hou, Chao
    Wang, Zihua
    He, Wen
    Zhang, Wei
    NANOSCALE, 2025, 17 (07) : 3537 - 3548
  • [5] Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies
    Bafleh, Wjdan S.
    Abdulsamad, Haia M. R.
    Al-Qaraghuli, Sally M.
    El Khatib, Riwa Y.
    Elbahrawi, Rawdah Taha
    Abdukadir, Azhar Mohamud
    Alsawae, Shaima M.
    Dimassi, Zakia
    Hamdan, Hamdan
    Kashir, Junaid
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [6] mRNA-Based Therapeutics in Cancer Treatment
    Sun, Han
    Zhang, Yu
    Wang, Ge
    Yang, Wen
    Xu, Yingjie
    PHARMACEUTICS, 2023, 15 (02)
  • [7] Development of mRNA-based therapeutics for proliferative vitreoretinopathy
    O'Hare, Michael
    Miller, William Phillip
    Arevalo-Alquichire, Said
    Rossin, Elizabeth J.
    Eliott, Dean
    Shu, Daisy Y.
    Rejman, Joanna
    Kim, Leo A.
    Arboleda-Velasquez, Joseph
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [8] Scaling for effective manufacturing of mRNA-based therapeutics
    Lee, Eunseo
    European Pharmaceutical Review, 2023, 28 (05): : 70 - 74
  • [9] mRNA-based therapeutics for mitochondrial optic neuropathies
    Lenaers, Guy
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [10] Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities
    Li, De-feng
    Liu, Qi-song
    Yang, Mei-feng
    Xu, Hao-ming
    Zhu, Min-zheng
    Zhang, Yuan
    Xu, Jing
    Tian, Cheng-mei
    Yao, Jun
    Wang, Li-sheng
    Liang, Yu-jie
    BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, 8 (03)
12345