Role of Tie1 in Shear Stress and Atherosclerosis

被引：3

作者：

Woo, Kel Vin ^{[2
]}

Baldwin, H. Scott ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Sch Med, Dept Pediat,Div Cardiol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2011年 / 21卷 / 04期

关键词：

RECEPTOR-TYROSINE KINASE; VASCULAR ENDOTHELIAL-CELLS; LYMPHATIC VESSEL DEVELOPMENT; PLAQUE NEOVASCULARIZATION; DISTURBED FLOW; GROWTH; EXPRESSION; LESIONS; SURVIVAL; ATHEROGENESIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerotic plagues develop in a nonrandom manner along the vasculature following a hemodynamically determined distribution profile. The pathogenesis of shear stress-induced inflammation and atherosclerotic lesion formation has led to discussions about personalized strategies in prevention and treatment. Recent discoveries involving the tyrosine kinase receptor Tie1 in (1) mechanotransduction, (2) inflammation, and (3) neovascularization have invigorated these efforts. In this review, we present the current understanding on Tie1 and its role in these key components of atherogenesis. (Trends Cardiovasc Med 2011; 21:118-123) (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：118 / 123

页数：6

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