Deep eutectic solvent for multi-component reactions: a highly efficient and reusable acidic catalyst for synthesis of 2,4,5-triaryl-1H-imidazoles

被引：19
|
作者：
Bakavoli, Mehdi [1 ]
Eshghi, Hossein [1 ]
Rahimizadeh, Mohammad [1 ]
Housaindokht, Mohammad Reza [1 ]
Mohammadi, Ali [1 ]
Monhemi, Hassan [1 ]
机构：
[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad, Iran
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 06期
关键词：
2,4,5-Trisubstituted imidazoles; Multi-component reactions; Choline chloride; Deep eutectic solvent; Oxalic acid; ONE-POT SYNTHESIS; TETRASUBSTITUTED IMIDAZOLES; HETEROGENEOUS CATALYST; MICROWAVE IRRADIATION; 2,4,5-TRIARYLIMIDAZOLES; ALDEHYDES;
D O I：
10.1007/s11164-013-1467-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Efficient synthesis of 2,4,5-trisubstituted imidazoles has been achieved by three-component cyclocondensation of benzil or benzoin, an aldehyde, and ammonium acetate by use of an acidic catalyst. The catalyst is a deep eutectic mixture of choline chloride and oxalic acid that is non-toxic and biodegradable. Crucial advantages of this process are high yields, shorter reaction times, easy work-up, purification of products by non-chromatographic methods, and reusability of the catalyst.
引用
收藏
页码：3497 / 3505
页数：9
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