Preparation and characterization of letrozole-loaded poly(d,l-lactide) nanoparticles for drug delivery in breast cancer therapy

被引:25
|
作者
Alemrayat, Bayan [1 ]
Elhissi, Abdelbary [1 ,2 ]
Younes, Husam M. [1 ,2 ]
机构
[1] Qatar Univ, Coll Pharm, Pharmaceut & Polymer Drug Delivery Res Lab, POB 2713, Doha, Qatar
[2] Qatar Univ, Off Res & Grad Studies, Doha, Qatar
关键词
Breast cancer; letrozole; poly(d; l-lactide); nanoparticles; sustained drug release; VITRO RELEASE KINETICS; POLYMERIC NANOPARTICLES; POSTMENOPAUSAL WOMEN; DEGRADATION; FORMULATION; DIFFUSION; NANOSPHERES; EQUATION;
D O I
10.1080/10837450.2018.1455698
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism, and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to control the release, potentially maximize the therapeutic efficiency, and minimize the side effects of the drug. LTZ was incorporated into poly(d,l-lactide) (PDLLA) NPs by employing the emulsion-solvent evaporation technique using a range of drug concentrations. Loaded drug and drug-polymer interactions were studied using X-ray diffraction and NPs morphology was evaluated using scanning electron microscopy (SEM). Particle size distribution (PSD) and zeta potential of the NPs were analyzed using dynamic light scattering (DLS) and laser Doppler velocimetry (LDV), respectively. Drug content and release profile studies were carried out and determined using ultra performance liquid chromatography (UPLC). The yield of LTZ-PDLLA NPs reached as high as 85%. The NPs were spherical and smooth, regardless of LTZ concentration in the formulation. However, particle size increased from 241.6 +/- 1.2 to 348.7 +/- 6.1 nm upon increasing LTZ concentration from 0 to 30% w/w, with entrapment efficiencies reaching up to 96.8%. Drug release from the polymeric matrix was best described by Higuchi model with a predominant diffusion-based mechanism. More than 15, 46, and 86% of LTZ was released in a controlled fashion over 30 d from the 10, 20, and 30% LTZ-PDLLA NPs, respectively. Overall, LTZ-PDLLA NPs were designed with appropriate size and surface charge, high drug loading, superior entrapment efficiency, and prolonged release profile.
引用
收藏
页码:235 / 242
页数:8
相关论文
共 50 条
  • [41] Synthesis and drug controlled release of block copolymers of poly(L-lactide) with poly(D,L-lactide) and related monomers
    Feng, XD
    Jia, Y
    MACROMOLECULAR SYMPOSIA, 1997, 118 : 625 - 630
  • [42] Highly Stable Docetaxel-Loaded Nanoparticles Based on Poly(D,L-lactide)-b-Poly(ethylene glycol) for Cancer Treatment: Preparation, Characterization, and In Vitro Cytotoxicity Studies
    Kuznetsova, Ekaterina V.
    Sedush, Nikita G.
    Puchkova, Yulia A.
    Aleshin, Sergei V.
    Yastremsky, Evgeny V.
    Nazarov, Alexey A.
    Chvalun, Sergei N.
    POLYMERS, 2023, 15 (10)
  • [43] Thermoresponsive Gelatin/Monomethoxy Poly(Ethylene Glycol)–Poly(d,l-lactide) Hydrogels: Formulation, Characterization, and Antibacterial Drug Delivery
    Hu Yang
    Weiyuan John Kao
    Pharmaceutical Research, 2006, 23 : 205 - 214
  • [44] Thermoresponsive gelatin/monomethoxy poly(ethylene glycol)-poly(D,L-lactide) hydrogels: Formulation, characterization, and antibacterial drug delivery
    Yang, H
    Kao, WYJ
    PHARMACEUTICAL RESEARCH, 2006, 23 (01) : 205 - 214
  • [45] Preparation and characterization of biodegradable poly(L-lactide)/chitosan blends
    Chen, C
    Dong, L
    Cheung, MK
    EUROPEAN POLYMER JOURNAL, 2005, 41 (05) : 958 - 966
  • [46] Preparation of drug-loaded microspheres of linear and star-shaped poly(D,L-lactide)s and their drug release behaviors
    Baimark, Yodthong
    Srisa-ard, Mangkorn
    JOURNAL OF APPLIED POLYMER SCIENCE, 2012, 124 (05) : 3871 - 3878
  • [47] Size-tunable nanoparticles composed of dextran-b-poly(D,L-lactide) for drug delivery applications
    Verma, Mohit S.
    Liu, Shengyan
    Chen, Yih Y.
    Meerasa, Ameena
    Gu, Frank X.
    NANO RESEARCH, 2012, 5 (01) : 49 - 61
  • [48] Size-tunable nanoparticles composed of dextran-b-poly(D,L-lactide) for drug delivery applications
    Mohit S. Verma
    Shengyan Liu
    Yih Y. Chen
    Ameena Meerasa
    Frank X. Gu
    Nano Research, 2012, 5 : 49 - 61
  • [49] Stability study of nanoparticles of poly(Ε-caprolactone), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide)
    Univ. Cathol. de Louvain, U. de Pharmacie Galénique, Brussels, Belgium
    不详
    BIOMATERIALS, 22 (2191-2197):
  • [50] In Situ Preparation and Characterization of a Novel Gelatin/Poly(D,L-lactide)/Hydroxyapatite Nanocomposite
    Zheng, Xiaotong
    Zhou, Shaobing
    Xiao, Yu
    Yu, Xiongjun
    Feng, Bo
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2009, 91B (01) : 181 - 190