Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates

被引：17
|
作者：
Lewis, Brittany B. [1 ]
Carter, Rebecca A. [1 ]
Pamer, Eric G. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Immunol Programs, Sloan Kettering Inst, Infect Dis Serv,Dept Med, New York, NY 10065 USA
来源：
ANAEROBE | 2016年 / 41卷
基金：
美国国家卫生研究院;
关键词：
Clostridium difficile; Secondary bile acid; SPORE GERMINATION; DISEASE SEVERITY; INFECTION; EPIDEMIC; EMERGENCE; SALTS; RESISTANCE; EFFICIENCY; OUTBREAK; RIBOTYPE;
D O I：
10.1016/j.anaerobe.2016.05.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：32 / 36
页数：5
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