Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue

被引：24

作者：

Hentall, PL ^{[1
]}

Flowers, N ^{[1
]}

Bugg, TDH ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 20期

关键词：

D O I：

10.1039/b107634p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.

引用

页码：2098 / 2099

页数：2

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