Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue

被引：24
|
作者：
Hentall, PL [1 ]
Flowers, N [1 ]
Bugg, TDH [1 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
来源：
CHEMICAL COMMUNICATIONS | 2001年 / 20期
关键词：
D O I：
10.1039/b107634p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.
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页码：2098 / 2099
页数：2
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