Tuning Bacterial Attachment and Detachment via the Thickness and Dispersity of a pH-Responsive Polymer Brush

被引:46
|
作者
Yadav, Vivek [1 ]
Jannes-Lizcano, Yuly Andrea [1 ]
Dewangan, Narendra K. [1 ]
Park, Nayoung [1 ]
Li, Tzu-Han [3 ]
Robertson, Megan L. [1 ,2 ]
Conrad, Jacinta C. [1 ]
机构
[1] Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77204 USA
[2] Univ Houston, Dept Chem, Univ Pk, Houston, TX 77204 USA
[3] Univ Houston, Mat Engn Program, Houston, TX 77204 USA
基金
美国国家科学基金会;
关键词
antifouling; polymer brushes; pH-responsive polymers; bacterial attachment; bacterial detachment; Staphylococcus epidermidis; WEAK POLYELECTROLYTE BRUSHES; POLY(ACRYLIC ACID) BRUSHES; BIOFILM FORMATION; PROTEIN ADSORPTION; GRAFTING DENSITY; CELL-ADHESION; ANTIBACTERIAL SURFACE; FILM THICKNESS; CHAIN-LENGTH; BEHAVIOR;
D O I
10.1021/acsami.7b14416
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
We investigated the effect of two brush parameters, thickness and dispersity in the molecular weight distribution, on the adhesion of bacteria to pH-responsive poly(acrylic acid) (PAA) brushes synthesized using surface initiated atom transfer radical polymerization. The attachment and detachment of Staphylococcus epidermidis to PAA brushes at pH 4 and pH 9, respectively, were examined with confocal microscopy. An optimal range of brush thickness, 13-18 nm, was identified for minimizing bacterial adhesion on PAA brushes at pH 4, and bacterial attachment did not depend on the brush dispersity. Increasing either the brush thickness or dispersity detached bacteria from the brushes when the pH was increased from 4 to 9. Bacterial detachment likely arose from an enhanced actuation effect in thick or high-dispersity brushes, as PAA brushes change conformation from collapsed to extended states when the pH is increased from 4 to 9. These results suggest that manipulating the molecular weight distribution provides a route to separately tune the attachment and detachment of bacteria.
引用
收藏
页码:44900 / 44910
页数:11
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