Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study

被引：32
|
作者：
Sanabria, Marciana [1 ]
Cucielo, Maira Smaniotto [1 ]
Guerra, Marina Trevizan [1 ]
Borges, Cibele dos Santos [1 ]
Banzato, Thais Petrochelli [1 ]
Perobelli, Juliana Elaine [1 ]
Araujo Leite, Gabriel Adan [1 ]
Anselmo-Franci, Janete Aparecida [2 ]
Kempinas, Wilma De Grava [1 ]
机构：
[1] Univ Estadual Paulista, Lab Reprod & Dev Biol & Toxicol, Dept Morphol, Inst Biosci Botucatu,UNESP, BR-18618970 Botucatu, SP, Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP, Brazil
来源：
REPRODUCTIVE TOXICOLOGY | 2016年 / 65卷
基金：
巴西圣保罗研究基金会;
关键词：
Dioxin; Epididymis; Sperm quality; Fertility; Transgenerational effect; LACTATIONAL 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN EXPOSURE; EPIDIDYMAL SPERM; IN-UTERO; ENVIRONMENTAL ANTIANDROGENS; REPRODUCTIVE DEVELOPMENT; ANDROGEN RECEPTOR; SEX-RATIO; DIOXINS; SINGLE; TOXICITY;
D O I：
10.1016/j.reprotox.2016.06.019
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Exposure to Tetrachlorodibenzo-p-dioxin (TCDD) in male rats promotes, decreased sperm concentration, alterations in motility and in sperm transit time. We evaluated the effect transgenerational of in utero exposure to low doses TCDD in the sperm quality. Pregnant rats (F0) were exposed to 0.1; 0.5 and 1.0 mu g of TCDD, on gestational day 15, coincides with the end of most organogenesis in the fetus. Adult male offspring (F1, F2 and F3 generation) were investigated for fertility after artificial insemination in utero. After collection of the uterus and ovaries, the numbers of corpora lutea and implants were determined. TCDD provoked alterations in sperm morphology and diminution in serum testosterone levels and sperm transit time in the cauda epididymis. The fertility significantly decreased in all the generations, at least at one dose. In conclusion, TCDD exposure decreases rat sperm quality and fertility in adult male offspring and this effects persist into the next generation. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：29 / 38
页数：10
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