A limited three-generation reproduction study on hexachlorocyclohexane (HCH) in rats

被引：6

作者：

Srivastava, MK ^{[1
]}

Raizada, RB ^{[1
]}

机构：

[1] Ind Toxicol Res Ctr, Pesticide Toxicol Lab, Lucknow 226001, Uttar Pradesh, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2000年 / 38卷 / 2-3期

关键词：

hexachlorocyclohexane; reproduction study; teratology; residues; histopathology; Druckrey rats;

D O I：

10.1016/S0278-6915(99)00152-0

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Dietary feeding of technical hexachlorocyclohexane (HCH) at 125 and 250 ppm to rats have not shown any adverse effects on reproductive function and were comparable to control animals in a three-generation study. There were no major malformations, while some minor variants found were not compound or dose related. Despite some mild toxicological effects in rats of the P-0 generation, the litters of F-1B, F-2B and F-3B generations were devoid of any morphological or teratological changes. The presence of HCH residues in vital tissues of F-3B pups have indicated transmigration of HCH in preceding generations but not to an extent that produced adverse effects. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：195 / 201

页数：7

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