Using Neuroimaging to Study the Effects of Pain, Analgesia, and Anesthesia on Brain Development

被引：6

作者：

Chen, Jerri ^{[1
]}

Gadi, Ghadah U. ^{[1
]}

Panigrahy, Ashok ^{[2
]}

Tam, Emily W. Y. ^{[3
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Anesthesiol, New York, NY USA

[2] Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA USA

[3] Univ Toronto, Dept Pediat Neurol, Toronto, ON, Canada

来源：

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY | 2019年 / 31卷 / 01期

关键词：

pediatric anesthesia; neurodevelopment; brain development; neuroimaging; preterm newborns; pain; analgesia; neurocognitive outcomes; PROCEDURAL PAIN; EARLY EXPOSURE; GENERAL-ANESTHESIA; CHILDHOOD EXPOSURE; OUTCOMES; AGE;

D O I：

10.1097/ANA.0000000000000549

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Neuroimaging has been increasingly used as a modality to study the impact of pain, analgesia, and anesthetics on pediatric neurodevelopment. The sixth biennial Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium addressed the 2016 US Food and Drug Administration drug safety warning regarding the potential neurotoxic effects of commonly used anesthetic and sedative medications in children, and included a session discussing the use of various neuroimaging techniques, to detect structural, metabolic, and functional brain changes that can occur with exposure to pain and to anesthetic medications. The presenters concluded that advanced multimodal magnetic resonance imaging techniques are useful in detecting the aforementioned changes, which were found to be pain-specific and anesthetic agent-specific.

引用

页码：119 / 121

页数：3

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